Diva D De León Selected Research

Congenital Hyperinsulinism

4/2022	Congenital hyperinsulinism: localization of a focal lesion with 18F-FDOPA positron emission tomography.
1/2022	Exendin-(9-39) Effects on Glucose and Insulin in Children With Congenital Hyperinsulinism During Fasting and During a Meal and a Protein Challenge.
11/2021	The Bihormonal Bionic Pancreas Improves Glycemic Control in Individuals With Hyperinsulinism and Postpancreatectomy Diabetes: A Pilot Study.
1/2021	Gut Microbiome Profile After Pancreatectomy in Infants With Congenital Hyperinsulinism.
1/2020	Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.
1/2019	Continuous Glucose Monitoring Systems: Are They Useful for Evaluating Glycemic Control in Children with Hyperinsulinism?
1/2019	Continuous Intragastric Dextrose: A Therapeutic Option for Refractory Hypoglycemia in Congenital Hyperinsulinism.
12/2018	Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide.
1/2018	A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1-/- mouse model of KATP hyperinsulinism.
1/2018	Population pharmacokinetics of exendin-(9-39) and clinical dose selection in patients with congenital hyperinsulinism.

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Diva D De León Research Topics

Disease

24	Hypoglycemia (Reactive Hypoglycemia) 04/2022 - 01/2007
17	Hyperinsulinism (Hyperinsulinemia) 01/2022 - 01/2007
16	Congenital Hyperinsulinism 04/2022 - 01/2007
2	Insulin Resistance 01/2018 - 09/2008
2	6 familial Hyperinsulinemic hypoglycemia 12/2017 - 02/2013
2	Hyperglycemia 10/2011 - 02/2003
1	Hyperammonemia 01/2022
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022
1	Thrombocytopenia (Thrombopenia) 12/2018
1	Hyperuricemia 12/2018
1	Neutropenia 12/2018
1	Adrenocorticotropic hormone deficiency 01/2018
1	Disease Progression 01/2018
1	Necrotizing Enterocolitis 01/2016
1	Dumping Syndrome (Syndrome, Dumping) 01/2016
1	Beckwith-Wiedemann Syndrome (Exomphalos Macroglossia Gigantism Syndrome) 01/2016
1	Seizures (Absence Seizure) 11/2013
1	Ketosis 01/2013
1	Fanconi Syndrome (Syndrome, Fanconi) 10/2012
1	Glycogen Storage Disease (Glycogenosis) 10/2012
1	Type 1 Maturity-Onset Diabetes of the Young 10/2012
1	Type 3 Maturity-Onset Diabetes of the Young 10/2012
1	Hypophosphatemic Rickets 10/2012
1	Diarrhea 07/2011
1	Weight Gain 04/2010
1	Psychotic Disorders (Schizoaffective Disorder) 04/2010
1	Body Weight (Weight, Body) 09/2008
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2007
1	Type 2 Diabetes Mellitus (MODY) 01/2006
1	Diabetes Mellitus 01/2006
1	Neoplasm Metastasis (Metastasis) 10/2002
1	Adrenocortical Carcinoma 10/2002
1	Cushing Syndrome 10/2002

Drug/Important Bio-Agent (IBA)

11	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 09/2008
9	Insulin (Novolin)FDA Link 04/2022 - 01/2007
5	Diazoxide (Hyperstat)FDA Link 12/2018 - 10/2012
4	exendin (9-39)IBA 01/2022 - 09/2008
4	Glutamate DehydrogenaseIBA 01/2022 - 01/2007
4	Glucagon (Glukagon)FDA Link 01/2020 - 01/2013
4	KATP ChannelsIBA 01/2018 - 01/2007
3	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2016 - 01/2006
3	Adenosine Triphosphate (ATP)IBA 10/2012 - 01/2007
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2017
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2019 - 11/2013
2	Octreotide (Sandostatin)FDA LinkGeneric 01/2018 - 01/2016
2	GlucokinaseIBA 02/2013 - 01/2007
2	Blood Glucose (Blood Sugar)IBA 10/2012 - 10/2011
1	fluorodopa F 18IBA 04/2022
1	Tuberculin (PPD)IBA 11/2021
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2020
1	Pharmaceutical PreparationsIBA 12/2018
1	Insulin ReceptorIBA 01/2018
1	Hormones (Hormone)IBA 01/2018
1	Sirolimus (Rapamycin)FDA Link 01/2018
1	KetonesIBA 01/2018
1	Monoclonal AntibodiesIBA 01/2018
1	Growth Hormone (Somatotropin)IBA 01/2018
1	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2018
1	Nonesterified Fatty Acids (NEFA)IBA 12/2013
1	3-Hydroxybutyric Acid (beta-Hydroxybutyric Acid)IBA 12/2013
1	C-PeptideIBA 01/2013
1	Glucagon-Like Peptide-1 ReceptorIBA 10/2012
1	NucleotidesIBA 03/2012
1	Nonsense Codon (Nonsense Mutation)IBA 07/2011
1	Clozapine (Clozaril)FDA LinkGeneric 04/2010
1	Metformin (Glucophage)FDA LinkGeneric 04/2010
1	EnzymesIBA 01/2007
1	3-Hydroxyacyl-CoA DehydrogenaseIBA 01/2007
1	PotassiumIBA 01/2007
1	Sulfonylurea ReceptorsIBA 01/2007
1	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2006
1	salicylhydroxamic acid (SHAM)IBA 02/2003
1	Cortodoxone (11 Deoxycortisol)IBA 10/2002
1	Mitotane (Lysodren)FDA Link 10/2002
1	SteroidsIBA 10/2002

Therapy/Procedure

9	Therapeutics 04/2022 - 01/2007
9	Pancreatectomy 04/2022 - 01/2007
3	Glycemic Control 11/2021 - 01/2018
2	Fundoplication 01/2016 - 01/2009
1	Drug Therapy (Chemotherapy) 01/2022
1	Maintenance Chemotherapy 01/2022
1	Enteral Nutrition (Feeding, Tube) 01/2019